DEVELOPMENTAL ROLE OF NEUROMODULATION

Neuromodulators are important for brain development. Altered neuromodulatory signalling is associated with mental conditions with developmental bases (for instance, schizophrenia and autism). We seek to study how neuromodulators control brain function and cognition, with a particular emphasis on serotonin. We manipulate neuromodulatory tone during early postnatal development and test the effect of these manipulations on learning and brain activity in the developing and adult brain.

 

TECHNIQUES

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LEARNING TASKS IN RODENTS

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PATCH CLAMP ELECTROPHYSIOLOGY

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PHARMACOLOGY

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OPTOGENETICS / PHARMACOGENETICS

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IMMUNOHISTOCHEMISTRY

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IMAGING OF NEURAL ACTIVITY

 

Related publications

Bocchio M*, Gouny C*, Angulo-Garcia D, Toulat T, Quiroli E, Baude A, Cossart R. Hippocampal hub neurons maintain distinct connectivity throughout their lifetime. Nature Communications 11:4559. 

Cavalieri D, Angelova A, Islah A, Lopez C,  Bocchio M, Baude A, Cossart C. CA1 pyramidal cell diversity is rooted in the time of neurogenesis. eLife, 10:e69270