NEUROMODULATION OF HUMAN CORTICAL CIRCUITS

We study the neuromodulation of human cortical circuits. We obtain small chunks of living human brain tissue resected during neurosurgeries. This allows us to prepare acute human brain slices and record neural activity for several hours. We use pharmacology to alter neuromodulatory tone. This is done in collaboration with the Faculty of Medical Sciences at Newcastle University and the Neurosurgery Department at the Royal Victoria Infirmary.

 

TECHNIQUES

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PATCH CLAMP ELECTROPHYSIOLOGY

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PHARMACOLOGY

 

Related publications

Bocchio M, Lukacs IP, Stacey R, Plaha P, Apostolopoulos V, Livermore L, Sen A, Ansorge  O, Gillies MJ, Somogyi P, Capogna M. Group II Metabotropic Glutamate Receptors Mediate Presynaptic Inhibition of Excitatory Transmission in Pyramidal Neurons of the Human Cerebral Cortex. Frontiers in Cellular Neuroscience 12, 508.